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Electrochemical Oxidative Difunctionalization of Alkenes to Access α-Oxygenated Ketones

Changhui Dai, Yijie Shen, Yifan Wei, Ping Liu* and Peipei Sun*

*School of Chemistry and Materials Science, Nanjing Normal University, Nanjing 210023, China, Email:,

C. Dai, Y. Shen, Y. Wei, P. Liu, P. Sun, J. Org. Chem., 2021, 86, 13711-13719.

DOI: 10.1021/acs.joc.1c01831

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The combination of electrochemical synthesis and aerobic oxidation enables a transition-metal-free dioxygenation of alkenes to provide α-oxygenated ketones in an eco-friendly fashion. A wide range of alkenes and N-hydroxyimides provided α-oxygenated ketones in good yields.

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proposed mechanism

Key Words

α-hydroxyketones (oxidation, α-oxygenation), hydroxylamines, oxygen, electrochemistry

ID: J42-Y2021