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Construction of a Pyrimidine Framework through [3 + 2 + 1] Annulation of Amidines, Ketones, and N,N-Dimethylaminoethanol as One Carbon Donor

Zemin Qin, Yongmin Ma* and Fanzhu Li*

*Taizhou University, Taizhou 318000; Zhejiang Chinese Medical University, Hangzhou 310053, P R China, Email:,

Z. Qin, Y. Ma, F. Li, J. Org. Chem., 2021, 86, 13734-13743.

DOI: 10.1021/acs.joc.1c01847

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An efficient, facile, and eco-friendly synthesis of pyrimidine derivatives involves an oxidative [3 + 2 + 1] three-component annulation of amidines, ketones, and N,N-dimethylaminoethanol as the one carbon source. The reaction tolerates many important functional groups.

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proposed mechanism

Key Words

pyrimidines, oxygen, multicomponent reactions

ID: J42-Y2021