Pd-Catalyzed Indole Synthesis via C-H Activation and Bisamination Sequence with Diaziridinone
Jianjun Wang, Xiaofeng Sun, Daguo Hu and Yian Shi*
*Institute of Natural and Sythetic Organic Chemistry, Changzhou University, Changzhou 213164, China,
Email: shiyian
cczu.edu.cn
J.-W. Ren, M.-N. Tong, Y.-F. Zhao, F. Ni, Org. Lett., 2021, 23, 7497-7502.
DOI: 10.1021/acs.orglett.1c02757
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Abstract
A wide variety of indoles can be obtained in good yields from readily available vinyl bromides and diaziridinone. The Pd-catalyzed reaction likely proceeds through a sequential aryl C-H activation and bisamination of a resulting pallada(II)cycle.
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synthesis of bioactive indoles
proposed mechanism
Key Words
ID: J54-Y2021
