Organic Chemistry Portal

Abstracts

Search:

Photocatalytic Activation of Elemental Sulfur Enables a Chemoselective Three-Component Thioesterification

Sho Murakami, Takeshi Nanjo and Yoshiji Takemoto*

*Graduate School of Pharmaceutical Sciences, Kyoto University, Yoshida, Sakyo-ku, Kyoto 606-8501, Japan, Email: takemotopharm.kyoto-u.ac.jp

S. Murakami, T. Nanjo, Y. Takemoto, Org. Lett., 2021, 23, 7650-7655.

DOI: 10.1021/acs.orglett.1c02904


Abstract

The photocatalytic activation of elemental sulfur enables a mild, rapid, and chemoselective three-component thioesterification in the presence of olefins and α-ketoacids. This novel reaction is characterized by high yields and a broad substrate scope.

see article for more examples

proposed mechanism



Key Words

thioesters (acylation, alkylation), multicomponent reactions, photochemistry


ID: J54-Y2021