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Metal-Free Solvent Promoted Oxidation of Benzylic Secondary Amines to Nitrones with H2O2

Álisson Silva Granato, Giovanni Wilson Amarante and Javier Adrio*

*Departamento de Química Orgánica, Facultad de Ciencias, Universidad Autónoma de Madrid, Cantoblanco, 28049 Madrid, Spain, Email:

A. S. Granato, G. W. Amarante, J. Adrio, J. Org. Chem., 2021, 86, 13817-13823.

DOI: 10.1021/acs.joc.1c01888


A catalyst-free oxidation of benzylic secondary amines using H2O2 in MeOH or CH2CN provides a selective access to a variety of C-aryl nitrones in good yields.

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Key Words

nitrones, hydrogen peroxide

ID: J42-Y2021