α-Xanthylmethyl Ketones from α-Diazo ketones
Pedro López-Mendoza, Luis D. Miranda*
*Instituto de Química, Universidad Nacional Autónoma de México, Circuito Exterior S. N., Ciudad Universitaria, Coyoacán, Ciudad de México, 04510, México,
Email: lmiranda
unam.com
P. López-Mendoza, L. D. Miranda, Synthesis, 2021, 53, 3777-3790.
DOI: 10.1055/a-1513-9968
see article for more reactions
Abstract
A simple and efficient method to obtain α-xanthylmethyl ketones from α-diazo ketones proceeds through a protonation/nucleophilic substitution sequence in the presence of p-toluenesulfonic acid and potassium ethyl xanthogenate as the nucleophile. The reaction provides a broad variety of xanthates.
see article for more examples
Key Words
xanthates, α-diazo ketones, α-xanthylmethyl ketones, free radicals, nucleophilic substitution
ID: J66-Y2021
