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Palladium-Catalyzed Reductive Aminocarbonylation of Benzylammonium Triflates with o-Nitrobenzaldehydes for the Synthesis of 3-Arylquinolin-2(1H)-ones

Yongzhu Liu, Xinxin Qi* and Xiao-Feng Wu*

*Department of Chemistry, Zhejiang Sci-Tech University, Hangzhou 310018; Dalian Institute of Chemical Physics, CAS, Dalian, Liaoning 116023, China, Email:,

Y. Liu, X. Qi, X.-F. Wu, J. Org. Chem., 2021, 86, 13824-13832.

DOI: 10.1021/acs.joc.1c01984


A palladium-catalyzed synthesis of 3-arylquinolin-2(1H)-ones proceeds through a reductive aminocarbonylation of benzylic ammonium triflates with o-nitrobenzaldehydes. The reaction provides a wide range of 3-arylquinolin-2(1H)-ones in good yields with very good functional group compatibility.

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proposed mechanism

Key Words

2-quinolones, multicomponent reactions

ID: J42-Y2021