Ozone-Mediated Amine Oxidation and Beyond: A Solvent-Free, Flow-Chemistry Approach
Eric A. Skrotzki, Jaya Kishore Vandavasi and Stephen G. Newman*
*Department of Chemistry & Biomolecular Sciences, 10 Marie Curie, University of Ottawa, Ottawa, Ontario, Canada, K1N 6N5, Email: stephen.newmanuottawa.ca
E. A. Skrotzki, J. K. Vandavasi, S. G. Newman, J. Org. Chem., 2021, 86, 14169-14176.
see article for more reactions
The high reactivity of ozone and its propensity to overoxidize organic molecules, including most solvents can largely be mitigated by adsorbing both substrate and ozone onto silica gel, providing a solvent-free oxidation method. A flow-based packed bed reactor approach provides exceptional control of temperature and time for oxidation of amines to nitroalkanes and the synthesis of pyridine N-oxides.
see article for more examples