Mechanochemical Syntheses of N-Containing Heterocycles with TosMIC
Christian Schumacher, Claude Molitor, Sabrina Smid, Khai-Nghi Truong, Kari Rissanen and Carsten Bolm*
*Institute of Organic Chemistry, RWTH Aachen University, Landoltweg 1, D-52074 Aachen, Germany,
Email: Carsten.Bolm
oc.rwth-aachen.de
C. Schumacher, C. Molitor, S. Smid, K.-N. Truong, K. Rissanen, C. Bolm, J. Org. Chem., 2021, 86, 14213-14222.
DOI: 10.1021/acs.joc.1c01529
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Abstract
A mechanochemical van Leusen pyrrole synthesis provides 3,4-disubstitued pyrroles in good yields. The developed protocol is compatible with a range of electron-withdrawing groups and was also applied to a van Leusen oxazole synthesis.
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Key Words
pyrroles, mechanochemistry
ID: J42-Y2021
