Organic Chemistry Portal



High Turnover Pd/C Catalyst for Nitro Group Reductions in Water. One-Pot Sequences and Syntheses of Pharmaceutical Intermediates

Xiaohan Li, Ruchita R. Thakore, Balaram S. Takale*, Fabrice Gallou and Bruce H. Lipshutz*

*Department of Chemistry and Biochemistry, University of California, Santa Barbara, California 93106, United States, Email:,

X. Li, R. R. Thakore, B. S. Takale, F. Gallou, B. H. Lipshutz, Org. Lett., 2021, 23, 8114-8118.

DOI: 10.1021/acs.orglett.1c03258

see article for more reactions


Pd/C can be used as a catalyst for nitro group reductions at very low Pd loading either in the presence of triethylsilane as a transfer hydrogenating agent or simply using a hydrogen balloon. With this technology, a series of nitro compounds was reduced to the desired amines in high yields. Both the catalyst and surfactant were recycled several times without loss of activity.

see article for more examples


Carbonyl Iron Powder: A Reagent for Nitro Group Reductions under Aqueous Micellar Catalysis Conditions

N. R. Lee, A. A. Bikovtseva, M. Cortes-Clerget, F. Gallou, B. H. Lipshutz, Org. Lett., 2017, 19, 6518-6521.

Chemoselective Reductions of Nitroaromatics in Water at Room Temperature

S. M. Kelly, B. H. Lipshutz, Org. Lett., 2014, 16, 98-101.

Key Words

Reduction of Nitro Compounds, Hydrogen, Green Chemistry

ID: J54-Y2021