Mechanochemical Synthesis of Primary Amides
Jorge Gómez-Carpintero, J. Domingo Sánchez, J. Francisco González* and J. Carlos Menéndez*
*Departamento de Química en Ciencias Farmacéuticas, Facultad de Farmacia, Universidad Complutense, 28040 Madrid, Spain,
Email: jfgonzal
ucm.es, josecmucm.es
J. Gómez-Carpintero, J. D. Sánchez, J. F. González, J. C. Menéndez, J. Org. Chem., 2021, 86, 14232-14237.
DOI: 10.1021/acs.joc.1c02350
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Abstract
Ball milling of aromatic, heteroaromatic, vinylic, and aliphatic esters with ethanol and calcium nitride provides the corresponding primary amides in good yields. The transformation is compatible with a variety of functional groups and maintained the integrity of a stereocenter α to carbonyl.
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Key Words
amides, mechanochemistry
ID: J42-Y2021
