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Potassium tert-Butoxide Promoted Synthesis of Dihydroquinazolinones

Tridev Ghosh, Indradip Mandal, Soumya Jyoti Basak and Jyotirmayee Dash*

*School of Chemical Sciences, Indian Association for the Cultivation of Science, Jadavpur, Kolkata 700032, India, Email:

T. Ghosh, I. Mandal, S. J. Basak, J. Dash, J. Org. Chem., 2021, 86, 14695-14704.

DOI: 10.1021/acs.joc.1c01510

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A transition-metal-free reaction of 2-aminobenzonitriles with aldehydes in the presence of KOtBu provides dihydroquinazolinones in high yields at room temperature. The method is also compatible with ketones for the synthesis of 2,2-disubstituted dihydroquinazolinones.

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Key Words


ID: J42-Y2021