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α-Keto Acids as Triggers and Partners for the Synthesis of Quinazolinones, Quinoxalinones, Benzoxazinones, and Benzothiazoles in Water

Jian Huang, Wei Chen, Jiazhi Liang, Qin Yang, Yan Fan, Mu-Wang Chen* and Yiyuan Peng*

*Jiangxi Normal University, 99 Ziyang Avenue, Nanchang 330022, China, Email:,

J. Huang, W. Chen, J. Liang, Q. Yan, Y. Fan, M.-W. Chen, Y. Peng, J. Org. Chem., 2021, 86, 14866-14882.

DOI: 10.1021/acs.joc.1c01497

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Efficient reactions of α-keto acids with 2-aminobenzamides, 2-aminobenzenethiols, benzene-1,2-diamines, and 2-aminophenols provide quinazolinones, benzothiazoles, quinoxalinones, and benzoxazinones under catalyst-free conditions, using water as the solvent. Products can be easily purified through filtration and washing with ethanol (or crystallized).

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Key Words

quinazolinones, benzothiazoles, quinoxalinones, benzoxazinones

ID: J42-Y2021