α-Keto Acids as Triggers and Partners for the Synthesis of Quinazolinones, Quinoxalinones, Benzoxazinones, and Benzothiazoles in Water
Jian Huang, Wei Chen, Jiazhi Liang, Qin Yang, Yan Fan, Mu-Wang Chen* and Yiyuan Peng*
*Jiangxi Normal University, 99 Ziyang Avenue, Nanchang 330022, China, Email: chenmuwang2017126.com, yypengjxnu.edu.cn
J. Huang, W. Chen, J. Liang, Q. Yan, Y. Fan, M.-W. Chen, Y. Peng, J. Org. Chem., 2021, 86, 14866-14882.
DOI: 10.1021/acs.joc.1c01497
see article for more reactions
Abstract
Efficient reactions of α-keto acids with 2-aminobenzamides, 2-aminobenzenethiols, benzene-1,2-diamines, and 2-aminophenols provide quinazolinones, benzothiazoles, quinoxalinones, and benzoxazinones under catalyst-free conditions, using water as the solvent. Products can be easily purified through filtration and washing with ethanol (or crystallized).
see article for more examples
Key Words
quinazolinones, benzothiazoles, quinoxalinones, benzoxazinones
ID: J42-Y2021