Chiral Bifunctional Phosphine Ligand Enables Gold-Catalyzed Asymmetric Isomerization and Cyclization of Propargyl Sulfonamide into Chiral 3-Pyrroline
Xinpeng Cheng and Liming Zhang*
*Department of Chemistry and Biochemistry, University of California, Santa Barbara, Santa Barbara, California 93106, United States,
Email: zhang
chem.ucsb.edu
X. Cheng, L. Zhang, Org. Lett., 2021, 23, 8194-8198.
DOI: 10.1021/acs.orglett.1c02896
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Abstract
An asymmetric gold-ligand cooperative catalysis transforms readily accessible chiral/achiral propargylic sulfonamides into chiral 3-pyrrolines. Depending on the ligand enantiomer, 2,5-cis-3-pyrrolines are formed with excellent diastereoselectivities and 2,5-trans-3-pyrrolines with good diastereoselectivities.
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Key Words
ID: J54-Y2021
