1,2-Dibutoxyethane-Promoted Oxidative Cleavage of Olefins into Carboxylic Acids Using O2 Under Clean Conditions
Jinhua Ou, Hong Tan, Saiyu He, Wei Wang, Bonian Hu, Gang Yu and Kaijian Liu*
*Department of Chemistry and Bioengineering, Hunan University of Science and Engineering, Yongzhou 425100, China,
Email: kjl1982
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J. Ou, H. Tan, S. He, W. Wang, B. Hu, G. Yu, K. Liu, J. Org. Chem., 2021, 86, 14974-14982.
DOI: 10.1021/acs.joc.1c01701
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Abstract
The combination of 1,2-dibutoxyethane/O2 enables an effective and green oxidative cleavage of olefins to carboxylic acids in very good yields. This oxidation system offers excellent functional-group tolerance, is applicable for large-scale synthesis, and works without an external initiator, catalyst, or additive.
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proposed mechanism
Key Words
ID: J42-Y2021
