pH-Mediated Selective Synthesis of N-Allylic Alkylation or N-Alkylation Amines with Allylic Alcohols via an Iridium Catalyst in Water
Nianhua Luo, Yuhong Zhong, Hongling Shui and Renshi Luo*
*School of Pharmaceutical Sciences, Gannan Medical University, Ganzhou 341000, Jiangxi, P. R. China,
Email: luorenshi2010
163.com
N. Luo, Y. Zhong, H. Shui, R. Luo, J. Org. Chem., 2021, 86, 15509-15521.
DOI: 10.1021/acs.joc.1c01930
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Abstract
An iridium complex catalyzes pH-dependent selective N-allylation or N-alkylation of amines with allylic alcohols in outstanding yields with water as the environmental benign solvent.
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proposed mechanism
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Key Words
N-allylation, N-alkylation, formic acid
ID: J42-Y2021
