Organic Chemistry Portal

Abstracts

Search:

Cobalt-Catalyzed Vinylic C-H Addition to Formaldehyde: Synthesis of Butenolides from Acrylic Acids and HCHO

Shuling Yu, Chao Hong, Zhanxiang Liu and Yuhong Zhang*

*Department of Chemistry, Zhejiang University, Hangzhou 310027, China, Email: yhzhangzju.edu.cn

S. Yu, C. Hong, Z. Liu, Y. Zhang, Org. Lett., 2021, 23, 8359-8364.

DOI: 10.1021/acs.orglett.1c03095


see article for more reactions

Abstract

A carboxyl-assisted, cobalt-catalyzed C-H functionalization of acrylic acids with formaldehyde provides butenolides. An optional treatment of the reaction medium with Na2CO3 after the catalytic reaction gives γ-dihydroxymethylated butenolides in one pot.


see article for more examples

proposed mechanism



Key Words

butenolides


ID: J54-Y2021