Cobalt-Catalyzed Asymmetric 1,4-Hydroboration of Enones with HBpin
Xiang Ren and Zhan Lu*
*Department of Chemistry, Zhejiang University, Hangzhou 310027, China,
Email: luzhan
zju.edu.cn
X. Ren, Z. Lu, Org. Lett., 2021, 23, 8370-8374.
DOI: 10.1021/acs.orglett.1c03110
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Abstract
In an operationally simple protocol, a 8-OIQ cobalt complex catalyzes a chemo- and enantioselective 1,4-hydroboration of enones with HBpin to access a broad range of chiral β,β-disubstituted ketones with very good chemo- and enantioselectivties.
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proposed mechanism
Key Words
ID: J54-Y2021
