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Copper-Catalyzed Methoxylation of Aryl Bromides with 9-BBN-OMe

Jing-Ru Wang, Zhi-Qiang Song, Chen Li* and Dong-Hui Wang*

*Wuyi University, 22 Dongcheng Village, Jiangmen, Guangdong 529020; Shanghai Institute of Organic Chemistry, CAS, 345 Lingling Road, Shanghai 200032, China, Email:,

J.-R. Wang, Z.-Q. Song, C. Li, D.-H. Wang, Org. Lett., 2021, 23, 8450-8454.

DOI: 10.1021/acs.orglett.1c03172

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A Cu-catalyzed cross-coupling reaction between aryl bromides and 9-BBN-OMe provide aryl methyl ethers under mild conditions. The oxalamide ligand BHMPO plays a key role in the transformation. Various functional groups on bromobenzenes are well tolerated.

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Key Words

aryl ethers

ID: J54-Y2021