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Selective Electrochemical Oxidation of Functionalized Pyrrolidines

Nicholas R. Deprez*, Dane J. Clausen, Jia-Xuan Yan, Feng Peng, Shaoguang Zhang, Jongrock Kong and Yanguang Bai

*Process Research and Development, Merck & Co., Inc., Rahway, New Jersey 07065, United States, Email:

N. R. Deprez, D. J. Clausen, J.-X. Yan, F. Peng, S. Zhang, J. Kong, Y. Bai, Org. Lett., 2021, 23, 8834-8837.

DOI: 10.1021/acs.orglett.1c03338


A selective electrochemical aminoxyl-mediated Shono-type oxidation of pyrrolidines provides pyrrolidinones with high selectivity and functional group compatibility.

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Key Words

γ-lactams, electrochemistry, ABNO, organocatalysis

ID: J54-Y2021