Desulfonylative Electrocarboxylation with Carbon Dioxide

Jun-Song Zhong, Zi-Xin Yang, Cheng-Lin Ding, Ya-Feng Huang, Yi Zhao, Hong Yan and Ke-Yin Ye*

*Institute of Pharmaceutical Science and Technology, College of Chemistry, Fuzhou University, Fuzhou 350108, China, Email: kyyefzu.edu.cn

J.-S. Zhong, Z.-X. Yang, C.-L. Ding, Y.-F. Huang, Y. Zhao, H. Yan, K.-Y. Ye, J. Org. Chem., 2021, 86, 16162-16170.

DOI: 10.1021/acs.joc.1c01261

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Abstract

A highly efficient electrochemical desulfonylative carboxylation protocol takes advantage of CO₂ as the abundant C1 building block for the facile preparation of multifunctionalized carboxylic acids, including the nonsteroidal anti-inflammatory drug ibuprofen, under mild reaction conditions.

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Key Words

benzylation, carboxylation, electrochemistry

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ID: J42-Y2021