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Iridium-Catalyzed Transfer Hydrogenation for Construction of Quinolines from 2-Aminobenzyl Alcohols with Enones in Water

Nanhua Luo, Hongling Shui, Yuhong Zhong, Jiuzhong Huang, Renshi Luo*

*School of Pharmacy, Gannan Medical University, Ganzhou, Jiangxi Province, 341000, P. R. of China, Email:

N. Luo, H. Shui, Y. Zhong, J. Huang, R. Luo, Synthesis, 2021, 53, 4516-4524.

DOI: 10.1055/a-1545-7563

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An Ir-catalyzed synthesis of functionalized quinolines from 2-aminobenzyl alcohols and α,β-unsaturated ketones tolerates a broad range of functional groups, offers high efficiency, is environmentally benign, and can be performed on a gram scale. Alkali is essential for the high selectivities of this catalytic system.

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Key Words

iridium catalysis, transfer hydrogenation, quinolines, alcohols, enones, green chemistry

ID: J66-Y2021