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Palladium-Catalyzed Methylsulfonylation of Alkyl Halides Using Dimethyl Sulfite as SO2 Surrogate and Methyl Source

Yan-Hua Xin, Ying-Qiong Guo, Xing-Guo Zhang* and Chen-Liang Deng*

*College of Chemistry and Materials Engineering, Wenzhou University, Wenzhou 325035, China, Email:,

Y.-H. Xin, Y.-Q. Guo, X.-G. Zhang, C.-L. Deng, J. Org. Chem., 2021, 86, 17496-17503.

DOI: 10.1021/acs.joc.1c02188

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A palladium-catalyzed methylsulfonylation of alkyl halides with dimethyl sulfite enables an efficient synthesis of methyl sulfone derivatives. A variety of aryl and alkyl iodides underwent the sulfonylation smoothly to furnish methyl sulfones in good yields.

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proposed mechanism

Key Words

aryl sulfones

ID: J42-Y2021