Palladium-Catalyzed Methylsulfonylation of Alkyl Halides Using Dimethyl Sulfite as SO2 Surrogate and Methyl Source
Yan-Hua Xin, Ying-Qiong Guo, Xing-Guo Zhang* and Chen-Liang Deng*
*College of Chemistry and Materials Engineering, Wenzhou University, Wenzhou 325035, China, Email: zxgwzu.edu.cn, dcl78wzu.edu.cn
Y.-H. Xin, Y.-Q. Guo, X.-G. Zhang, C.-L. Deng, J. Org. Chem., 2021, 86, 17496-17503.
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A palladium-catalyzed methylsulfonylation of alkyl halides with dimethyl sulfite enables an efficient synthesis of methyl sulfone derivatives. A variety of aryl and alkyl iodides underwent the sulfonylation smoothly to furnish methyl sulfones in good yields.
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