Three-Component Reactions of α-CF₃ Carbonyls, NaN₃, and Amines for the Synthesis of NH-1,2,3-Triazoles

Leiyang Lv, Ge Gao, Yani Luo, Kuantao Mao and Zhiping Li*

*Department of Chemistry, Renmin University of China, Beijing 100872, China, Email: zhipingliruc.edu.cn

L. Lv, G. Gao, Y. Luo, K. Mao, Z. Li, J. Org. Chem., 2021, 86, 17197-17212.

DOI: 10.1021/acs.joc.1c02288

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Abstract

A three-component assembly of α-CF₃ carbonyls, NaN₃, and amines provides a variety of 5-amino NH-1,2,3-triazoles under transition-metal-free and open-air conditions. The method provides a general and operationally simple route to functionalized biologically important molecules. The NH-1,2,3-triazoles can be smoothly converted to N-2 alkylated 1,2,3-triazole products.

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proposed mechanisms

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Key Words

1,2,3-Triazoles, Multicomponent Reactions

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ID: J42-Y2021