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Metal- and Oxidant-Free Green Three-Component Desulfurization and Deamination Condensation Approach to Fully Substituted 1H-1,2,4-Triazol-3-amines and Their Photophysical Properties

Wei Guo*, Gongping Liu, Ling Deng, Weijie Mei, Xiaoying Zou, Yumei Zhong, Xiaoya Zhuo, Xiaolin Fan and Lvyin Zheng*

*Key Laboratory of Organo-Pharmaceutical Chemistry of Jiangxi Province, Gannan Normal University, Ganzhou 341000, China, Email:,

W. Guo, G. Liu, L. Deng, W. Mei, X. Zou, Y. Zhong, X. Zhuo, J. Org. Chem., 2021, 86, 17244-17248.

DOI: 10.1021/acs.joc.1c02313

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A metal- and oxidant-free three-component desulfurization and deamination condensation of amidines, isothiocyanates, and hydrazines provides structurally diverse fully substituted 1H-1,2,4-triazol-3-amines. This [2 + 1 + 2] cyclization strategy offers mild reaction conditions, environmental friendliness, and easy gram-scale applications.

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Key Words

1,2,4-triazoles, multicomponent reactions

ID: J42-Y2021