Environmentally Friendly and Recyclable CuCl₂-Mediated C-S Bond Coupling Strategy Using DMEDA as Ligand, Base, and Solvent

Guodong Shen*, Qichao Lu, Zeyou Wang, Weiwei Sun, Yalin Zhang, Xianqiang Huang*, Manman Sun, Zhiming Wang

*School of Chemistry and Chemical Engineering, Liaocheng University, 1 Hunan Avenue, Liaocheng 252000, Shandong, P. R. of China, Email: shenguodong33163.com, sunmmtzc.edu.cn

G. Shen, Q. Lu, Z. Wang, W. Sun, Y. Zhang, X. Huang, M. Sun, Z. Wang, Synthesis, 2022, 54, 184-198.

DOI: 10.1055/a-1561-5508

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Abstract

An environment-friendly and economic CuCl₂-catalyzed C-S bond-formation enables the synthesis of diaryl chalcogenides in very good yields from iodobenzenes and benzenethiols/1,2-diphenyldisulfanes in the presence of N,N'-dimethylethane-1,2-diamine (DMEDA) as ligand, base, and solvent. The catalytic system (CuCl₂/DMEDA) is inexpensive, conveniently separable, and recyclable.

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Key Words

aryl sulfides, Ullmann reaction, green chemistry

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ID: J66-Y2022