Lanthanide-Catalyzed Tandem Addition of Amines to Cyanoalkenes: Synthesis of Cyclic Amidines
Jinsong Hou, Gaosheng Yang* and Zhuo Chai
*Institute of Organic Chemistry, College of Chemistry and
Materials Science, Anhui Normal University, 189 South Jiuhua Road, Wuhu, Anhui
241002, China, Email: gshyang
ahnu.edu.cn
J. Hou, G. Yang, Z. Chai, J. Org. Chem., 2022, 87, 453-463.
DOI: 10.1021/acs.joc.1c02481
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Abstract
Simple trialkyl rare-earth metal complexes catalyze a highly atom-economic and stereoselective tandem insertion of aliphatic nitriles and unactivated alkenes to the N-H bond of secondary aliphatic amines to provide of cyclic amidines under mild reaction conditions.
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Key Words
ID: J42-Y2022
