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Nickel-Catalyzed Reductive Cross-Coupling of Aryl Bromides with Vinyl Acetate in Dimethyl Isosorbide as a Sustainable Solvent

Mincong Su, Xia Huang, Chuanhu Lei* and Jian Jin*

*Department of Chemistry, Shanghai University, 99 Shangda Road, Shanghai 200444; SIOC, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, China Email:,

M. Su, X. Huang, C. Lei, J. Jin, Org. Lett., 2022, 24, 354-358.

DOI: 10.1021/acs.orglett.1c04018


A mild nickel-catalyzed reductive cross-coupling between (hetero)aryl bromides and vinyl acetate provides a variety of vinyl arenes, heteroarenes, and benzoheterocycles. Importantly, dimethyl isosorbide as solvent makes this protocol more sustainable.

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proposed mechanism

Key Words

alkenylation, green chemistry, zinc

ID: J54-Y2022