Nickel-Catalyzed Reductive Cross-Coupling of Aryl Bromides with Vinyl Acetate in Dimethyl Isosorbide as a Sustainable Solvent
Mincong Su, Xia Huang, Chuanhu Lei* and Jian Jin*
*Department of Chemistry, Shanghai University, 99 Shangda Road, Shanghai 200444; SIOC, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, China
Email: chlei
shu.edu.cn, jjinsioc.ac.cn
M. Su, X. Huang, C. Lei, J. Jin, Org. Lett., 2022, 24, 354-358.
DOI: 10.1021/acs.orglett.1c04018
Abstract
A mild nickel-catalyzed reductive cross-coupling between (hetero)aryl bromides and vinyl acetate provides a variety of vinyl arenes, heteroarenes, and benzoheterocycles. Importantly, dimethyl isosorbide as solvent makes this protocol more sustainable.
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proposed mechanism
Key Words
alkenylation, green chemistry, zinc
ID: J54-Y2022
