Nickel-Catalyzed Enantioselective Hydroboration of Vinylarenes
Hai N. Tran and Levi M. Stanley*
*Department of Chemistry, Iowa State University, Ames, Iowa 50011, United States, Email: lstanleyiastate.edu
H. N. Tran, L. M. Stanley, Org. Lett., 2022, 24, 395-399.
A chiral nickel complex catalyzes a facile enantioselective hydroboration of vinylarenes to provide chiral benzylic boronate esters. Various vinylarenes react with bis(pinacolato)diboron in the presence of MeOH as a hydride source to form chiral boronate esters in good yields with high ee. Me4NF activates B2pin2 for ensuring fast transmetalation to achieve high enantioselectivities.
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