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Catalytic Amination of Phenols with Amines

Kai Chen, Qi-Kai Kang, Yuntong Li, Wen-Qiang Wu, Hui Zhu and Hang Shi*

*Key Laboratory of Precise Synthesis of Functional Molecules of Zhejiang Province, School of Science, Westlake University, 18 Shilongshan Road, Hangzhou 310024, Zhejiang Province, China, Email:

K. Chen, Q.-K. Kang, Y. Li, W. Giang, Wu, H. Zhu, H. Shi, J. Am. Chem. Soc., 2022, 144, 1144-1151.

DOI: 10.1021/jacs.1c12622


A rhodium-catalyzed amination of phenols provides diverse anilines, with water as the sole byproduct. The arenophilic rhodium catalyst facilitates the inherently difficult keto-enol tautomerization of phenols by means of π-coordination, allowing for the subsequent dehydrative condensation with amines.

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proposed mechanism

Key Words


ID: J48-Y2022