Iron-Catalyzed Ring Expansion of Cyclobutanols for the Synthesis of 1-Pyrrolines by Using MsONH₃OTf

Daijiao Zhuang, Tharcisse Gatera, Zhenyu An and Rulong Yan*

*State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, China, Email: yanrllzu.edu.cn

D. Zhuang, T. Gatera, Z. An, R. Yan, Org. Lett., 2022, 24, 771-775.

DOI: 10.1021/acs.orglett.1c04304

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Abstract

A synthesis of 1-pyrrolines in good yields from cyclobutanol derivatives and an aminating reagent (MsONH₃OTf) is achieved under mild conditions by C-N bond/C=N bond formation via ring expansion.

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proposed mechanism

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Key Words

1-pyrrolines

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ID: J54-Y2022