Preparation of (E)-1,3-Enyne Derivatives through Palladium Catalyzed Hydroalkynylation of Allenes
Zhi-Kai Liu, Ying Yang and Zhuang-Ping Zhan*
*Department of Chemistry College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, Fujian, PR China, Email: zpzhanxmu.edu.cn
Z.-K. Liu, Y. Yang, Z.-P. Zhan, J. Org. Chem., 2022, 87, 1589-1597.
DOI: 10.1021/acs.joc.1c02732
Abstract
A general and efficient palladium catalyzed hydroalkynylation of allenes provides synthetically versatile (E)-1,3-enyne derivatives with high regio- and stereoselectivity under mild conditions. The catalytic system tolerated a broad range of substrates.
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ID: J42-Y2022