Organic Chemistry Portal



Metal-Free, Rapid, and Highly Chemoselective Reduction of Aromatic Nitro Compounds at Room Temperature

Mingyeong Jang, Taeho Lim, Byoung Yong Park and Min Su Han*

*Department of Chemistry, Gwangju Institute of Science and Technology (GIST), Gwangju 61005, Republic of Korea, Email:

M. Jang, T. Lim, B. Y. Park, M. S. Han, J. Org. Chem., 2022, 87, 910-919.

DOI: 10.1021/acs.joc.1c01431

see article for more reactions


The use of tetrahydroxydiboron as reductant and 4,4′-bipyridine as organocatalyst enables a metal-free and highly chemoselective reduction of aromatic nitro compounds within 5 min at room temperature. Under optimal conditions, sensitive functional groups, such as vinyl, ethynyl, carbonyl, and halogen were tolerated.

see article for more examples

Key Words

reduction of nitro compounds, tetrahydroxydiboron, organocatalysis

ID: J42-Y2022