Regioselective Synthesis of N²-Aryl 1,2,3-Triazoles via Electro-oxidative Coupling of Enamines and Aryldiazonium Salts

Mrinmay Baidya, Samrat Mallick and Suman De Sarkar*

*Department of Chemical Sciences, Indian Institute of Science Education and Research Kolkata, Mohanpur 741246, West Bengal, India, Email: sdsiiserkol.ac.in

M. Baidya, S. Mallick, S. D. Sarkar, Org. Lett., 2022, 24, 1274-1279.

DOI: 10.1021/acs.orglett.1c04099

---

see article for more reactions

Abstract

A sequential C-N bond formation and electro-oxidative N-N coupling enables an efficient synthesis of of N²-Aryl 1,2,3-triazoles in very good yields under metal-free conditions from readily accessible 2-aminoacrylates and aryldiazonium salts. This method displays excellent functional group tolerance.

see article for more examples

proposed mechanism

---

---

Key Words

2H-1,2,3-triazoles, electrochemistry

---

ID: J54-Y2022