Chemodivergent Synthesis of Allylic Sulfones via Ligand-Controlled Coupling of Allenes with Sulfinic Acids
Jia-Hao Zeng, Ding-Chang Li, Sheng Zhang and Zhuang-Ping Zhan*
*Department of Chemistry, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, Fujian, People’s Republic of China,
Email: zpzhan
xmu.edu.cn
J. Zhang, Y. Wang, C. You, M. Shi, X. Mi, S. Luo, Org. Lett., 2022, 24, 1186-1189.
DOI: 10.1021/acs.orglett.1c04349
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Abstract
A chemodivergent protocol for Pd-catalyzed and ligand-controlled coupling of allenes with sulfinic acids provides straightforward and atom-economical access to branched allylic sulfones and linear allylic sulfones in good yields with high selectivities. This strategy features mild conditions, an unprecedented substrate scope, and functional group compatibility.
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proposed mechanism
DTBPF
Key Words
ID: J54-Y2022
