Iridium-Catalyzed Amidation of In Situ Prepared Silyl Ketene Acetals to Access α-Amino Esters
Yunyeong Gwon, Minhan Lee, Dongwook Kim and Sukbok Chang*
*Department of Chemistry, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, Korea,
Email: sbchang
kaist.ac.kr
J. Gwon, M. Lee, D. Kim, S. Chang, Org. Lett., 2022, 24, 1088-1093.
DOI: 10.1021/acs.orglett.1c04376
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Abstract
A convenient Ir-catalyzed amidation of silyl ketene acetals with an oxycarbonylnitrenoid provides α-amido esters. Silyl ketene acetals were prepared from esters, without separate purification. The α-amidation was facile for both α-aryl and α-alkyl esters.
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Key Words
ID: J54-Y2022
