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Synthesis of C3-Cyanomethylated Imidazo[1,2-a]pyridines via Ultrasound-Promoted Three-Component Reaction under Catalyst- and Oxidant-Free Conditions

Jie Zhang*, Yufeng Zhang, Jian Zhang, Qingguo Wu, Haifeng Yang*

*School of Animal Pharmaceutical Sciences, Jiangsu Agri-animal Husbandry Vocational College, Taizhou 225300, P. R. of China, Email:,

J. Zhang, Y. Zhang, J. Zhang, Q. Wu, H. Yang, Synlett, 2022, 33, 264-268.

DOI: 10.1055/a-1704-4822

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An ultrasound-promoted three-component reaction provides C3-cyanomethylated imidazo[1,2-a]pyridines under catalyst-free, oxidant-free, and mild conditions. A series of C3-cyanomethylated imidazo[1,2-a]pyridines were rapidly prepared with satisfactory yields and good functional group compatibility.

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Key Words

sonochemistry, multicomponent reactions, cyanomethylation, imidazo[1,2-a]pyridines, catalyst- and oxidant-free

ID: J72-Y2022