Synthesis of C3-Cyanomethylated Imidazo[1,2-a]pyridines via Ultrasound-Promoted Three-Component Reaction under Catalyst- and Oxidant-Free Conditions
Jie Zhang*, Yufeng Zhang, Jian Zhang, Qingguo Wu, Haifeng Yang*
*School of Animal Pharmaceutical Sciences, Jiangsu Agri-animal Husbandry Vocational College, Taizhou 225300, P. R. of China, Email: 2423907512qq.com, yhf8142sina.com
J. Zhang, Y. Zhang, J. Zhang, Q. Wu, H. Yang, Synlett, 2022, 33, 264-268.
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An ultrasound-promoted three-component reaction provides C3-cyanomethylated imidazo[1,2-a]pyridines under catalyst-free, oxidant-free, and mild conditions. A series of C3-cyanomethylated imidazo[1,2-a]pyridines were rapidly prepared with satisfactory yields and good functional group compatibility.
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