Cathodic Regioselective Coupling of Unactivated Aliphatic Ketones with Alkenes
Hongting Wu, Weihao Chen, Weijie Deng, Ling Yang, Xinling Li, Yunfei Hu, Yibiao Li, Lu Chen and Yubing Huang*
*School of Biotechnology and Health Sciences, Wuyi University, Jiangmen 529090, P. R. China,
Email: wyuchemhyb
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H. Wu, W. Chen, W. Deng, L. Yang, X. Li, Y. Hu, Y. Li, L. Chen, Y. Huang, Org. Lett., 2022, 24, 1412-1417.
DOI: 10.1021/acs.orglett.2c00314
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Abstract
Cathodic reduction enables a regioselective coupling of aliphatic ketones with alkenes via the formation of ketyl radicals and the activation of challenging alkenes under mild electrolysis conditions. This efficient protocol provides diverse tertiary alcohols with substrate-dependent regioselectivity.
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proposed mechanism
Key Words
alcohols, electrochemistry
ID: J54-Y2022
