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Cathodic Regioselective Coupling of Unactivated Aliphatic Ketones with Alkenes

Hongting Wu, Weihao Chen, Weijie Deng, Ling Yang, Xinling Li, Yunfei Hu, Yibiao Li, Lu Chen and Yubing Huang*

*School of Biotechnology and Health Sciences, Wuyi University, Jiangmen 529090, P. R. China, Email:

H. Wu, W. Chen, W. Deng, L. Yang, X. Li, Y. Hu, Y. Li, L. Chen, Y. Huang, Org. Lett., 2022, 24, 1412-1417.

DOI: 10.1021/acs.orglett.2c00314

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Cathodic reduction enables a regioselective coupling of aliphatic ketones with alkenes via the formation of ketyl radicals and the activation of challenging alkenes under mild electrolysis conditions. This efficient protocol provides diverse tertiary alcohols with substrate-dependent regioselectivity.

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proposed mechanism

Key Words

alcohols, electrochemistry

ID: J54-Y2022