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Water Mediated Direct Thioamidation of Aldehydes at Room Temperature

Ankush Gupta, Jigarkumar K. Vankar, Jaydeepbhai P. Jadav and Guddeangadi N. Gururaja*

*School of Chemical Sciences, Central University of Gujarat, Gandhinagar 382030, India, Email:

A. Gupta, J. K. Vankar, J. P. Jadav, G. N. Gururaja, J. Org. Chem., 2022, 87, 2410-2420.

DOI: 10.1021/acs.joc.1c02307

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Water mediates a greener and mild synthesis of thioamides with no input energy, additives, or catalysts. The presented protocol enables the conversion of readily available starting materials and the use of different array amines, and can easily be scaled-up.

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proposed mechanism

Key Words

Thioamides (amination, thionation), multicomponent reactions, Kindler Reaction

ID: J42-Y2022