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Ru-Catalyzed Defluorinative Alkylation or Catalyst-Free Hydroalkylation of gem-Difluoroalkenes Enabled by Visible Light

Fangran Liu, Zhen Zhuang, Qun Qian, Xiaofei Zhang* and Chunhao Yang*

*Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai 201203, P. R. China, Email:,

F. Liu, Z. Zhuang, Q. Qian, X. Zhang, C. Yang, J. Org. Chem., 2022, 87, 2730-2739.

DOI: 10.1021/acs.joc.1c02662

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A catalyst-induced defluorinative, alkylation or metal-free hydroalkylation of gem-difluoroalkenes provides a mild and practical approach to important and monofluoroalkenes and difluoromethylene-containing compounds under visible light irradiation with good yields.

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proposed mechanism

Key Words

alkenylation, fluoroalkenes, photochemistry, Hantzsch Ester

ID: J42-Y2022