Ru-Catalyzed Defluorinative Alkylation or Catalyst-Free Hydroalkylation of gem-Difluoroalkenes Enabled by Visible Light
Fangran Liu, Zhen Zhuang, Qun Qian, Xiaofei Zhang* and Chunhao Yang*
*Shanghai Institute of Materia Medica, Chinese Academy of
Sciences, 555 Zu Chong Zhi Road, Shanghai 201203, P. R. China, Email:
xiaofeizhang
simm.ac.cn, chyangsimm.ac.cn
F. Liu, Z. Zhuang, Q. Qian, X. Zhang, C. Yang, J. Org. Chem., 2022, 87, 2730-2739.
DOI: 10.1021/acs.joc.1c02662
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Abstract
A catalyst-induced defluorinative, alkylation or metal-free hydroalkylation of gem-difluoroalkenes provides a mild and practical approach to important and monofluoroalkenes and difluoromethylene-containing compounds under visible light irradiation with good yields.
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proposed mechanism
Key Words
alkenylation, fluoroalkenes, photochemistry, Hantzsch Ester
ID: J42-Y2022
