Organic Chemistry Portal

Abstracts

Search:

Recyclable Pd2dba3/XPhos/PEG-2000 System for Efficient Borylation of Aryl Chlorides: Practical Access to Aryl Boronates

Mingzhong Cai*, Chengkai Luo, Caifeng Xu, Bin Huang*

*College of Chemistry & Chemical Engineering, Jiangxi Normal University, Nanchang 330022, P. R. of China, Email: mzcaijxnu.edu.cn, huangb260163.com

M. Cai, C. Luo, C. Xu, B. Huang, Synthesis, 2022, 54, 153-160.

DOI: 10.1055/s-0037-1610787


see article for more reactions

Abstract

Pd2dba3/XPhos in poly(ethylene glycol) (PEG-2000) is  a highly stable and efficient catalyst system for the borylation of aryl chlorides with bis(pinacolato)diboron to provide a wide variety of aryl boronates in very good yields with high functional group tolerance. The crude products were easily isolated via simple extraction of the reaction mixture with cyclohexane and the catalyst phase could be recycled.


see article for more examples



Key Words

palladium, borylation, aryl chlorides, poly(ethylene glycol), catalyst recycling, Miyaura coupling


ID: J66-Y2022