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One-Pot Synthesis of α-Ketoamides from α-Keto Acids and Amines Using Ynamides as Coupling Reagents

Jianting Ma, Xue Cui, Junyu Xu, Yinfeng Tan, Yan Wang, Xuesong Wang* and Youbin Li*

*School of Pharmacy, Hainan Medical University, Haikou 571199, P.R. China, Email:,

J. Ma, X. Cui, J. Xu, Y. Tan, Y. Wang, X. Wang, Y. Li, J. Org. Chem., 2022, 87, 3661-3667.

DOI: 10.1021/acs.joc.1c02453

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Ynamides as coupling reagents enable a practical one-pot strategy for α-keto amide bond formation under extremely mild reaction conditions. Diversely structural α-ketoamides were afforded in very good yields. This reaction offers wide functional group tolerance and has potential applications in synthetic and medicinal chemistry.

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Key Words


ID: J42-Y2022