Visible Light-Promoted Synthesis of β-Keto Sulfoximines from N-Tosyl-Protected Sulfoximidoyl Chlorides
Peng Shi, Yongliang Tu, Chenyang Wang, Ding Ma and Carsten Bolm*
*Institute of Organic Chemistry, RWTH Aachen University, Landoltweg 1, 52074 Aachen, Germany,
Email: carsten.bolm
oc.rwth-aachen.de
P. Shi, Y. Tu, C. Wang, D. Ma, C. Bolm, J. Org. Chem., 2022, 87, 3817-3824.
DOI: 10.1021/acs.joc.1c02971
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Abstract
Visible light mediates a reaction of N-tosyl-protected sulfoximidoyl chlorides with aryl alkynes in the presence of air and a ruthenium photocatalyst to provide β-keto sulfoximines in good yields. The reaction offers high functional group tolerance.
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proposed mechanism
Key Words
sulfoximines, photochemistry, oxygen
ID: J42-Y2022
