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Synthesis of Hydrazides from N-Tosylhydrazones and Its Application in the Preparation of Indazolones

Siyu Zhang, Qian Zhang and Meng Tang*

*School of Pharmacy, Lanzhou University, Lanzhou 730000, P. R. China, Email:

S. Zhang, Q. Zhang, M. Tang, J. Org. Chem., 2022, 87, 3845-3850.

DOI: 10.1021/acs.joc.1c03037


A facile synthesis of hydrazides from N-tosylhydrazones under metal-free conditions was suitable for different substrates and tolerated various substituents. In a subsequent step, a series of indazolones could be prepared from corresponding o-bromobenzohydrazides under mild conditions.

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Key Words

hydrazides, NCS, indazolones, copper(II)

ID: J42-Y2022