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A Practically Unified Electrochemical Strategy for Ni-Catalyzed Decarboxylative Cross-Coupling of Aryl Trimethylammonium Salts

Xianqiang Kong*, Yiyi Chen, Xiaohui Chen, Zheng-Xuan Lu, Wei Wang, Shao-Fei Ni* and Zhong-Yan Cao*

*Changzhou Institute of Technology, Changzhou 213032; Shantou University, Shantou 515063, Guangdong; Henan University, Kaifeng 475004, China, Email:,,

X. Kong, Y. Chen, X. Chen, Z.-X. Lu, W. Wang, S.-F. Ni, Z.-Y. Cao, Org. Lett., 2022, 24, 2137-2142.

DOI: 10.1021/acs.orglett.2c00408

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The combination of electrocatalysis and nickel catalysis achieves a decarboxylative cross-coupling of four types of α-oxocarboxylic acids and their derivatives with aryl trimethylammonium salts under mild conditions. This strategy enables a practical synthesis of aryl ketones, amides, esters, and aldehydes.

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proposed mechanism

BPhen, Bathophenanthroline

Cyanation and cyanomethylation of trimethylammonium salts via electrochemical cleavage of C-N bonds

Y. Yan, J. Sun, G. Li, L. Yang, W. Zhang, R. Cao, C. Wang, J. Xiao, D. Xue, Org. Lett., 2022, 24, 2271-2275.

Key Words

aryl ketones, electrochemistry

ID: J54-Y2022