Base-Mediated Site-Selective Hydroamination of Alkenes
Ping Li, Boon Chong Lee, Xiaoxiang Zhang, Ming Joo Koh*
*Department of Chemistry, National University of Singapore, 4
Science Drive 2, 117544, Singapore, Email: chmkmj
nus.edu.sg
P. Li, B. C. Lee, X. Zhang, M. J. Koh, Synthesis, 2022, 54, 1566-1576.
DOI: 10.1055/a-1681-4720
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Abstract
A base-mediated hydroamination protocol with substoichiometric amounts of a hydrosilane and potassium tert-butoxide operates under mild conditions. Many aryl- and heteroatom-substituted olefins as well as arylamines are tolerated, affording the desired products with complete regioselectivity.
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Key Words
hydroamination, amines, arylamines, remote alkene functionalization, base-mediated, regioselectivity, transition-metal-free
ID: J66-Y2022
