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Synthesis of N-CF3 Amidines/Imidates/Thioimidates via N-CF3 Nitrilium Ions

Ru Zhong Zhang, Wanqiao Huang, Ru Xue Zhang, Cong Xu* and Mang Wang*

*College of Chemistry, Northeast Normal University, Changchun 130024, China, Email:,

R. Z. Zhang, W. Huang, R. X. Zhang, C. Xu, M. Wang, J. Sun, Org. Lett., 2022, 24, 2393-2398.

DOI: 10.1021/acs.orglett.2c00647


A N-trifluoromethylation of nitriles with PhICF3Cl followed by DMAP-catalyzed capture with N-, O-, or S-centered nucleophiles enables an efficient synthesis of a wide range of N-CF3 amidines, imidates, and thioimidates.

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Key Words

amidines, imidates, thioimidates

ID: J54-Y2022