Intramolecular Hydrogen Atom Transfer Hydroarylation of Alkenes toward δ-Lactams Using Cobalt-Photoredox Dual Catalysis
Yuto Yamaguchi, Yusuke Seino, Akihiko Suzuki, Yuji Kamei, Tatsuhiko Yoshino, Masahiro Kojima* and Shigeki Matsunaga*
*Faculty of Pharmaceutical Sciences, Hokkaido University,
Sapporo 060-0812, Japan, Email: m-kojima
pharm.hokudai.ac.jp,
smatsunapharm.hokudai.ac.jp
Y. Yamaguchi, Y. Seino, A. Suzuki, Y. Kamei, T. Yoshino, M. Kojima, S. Matunaga, Org. Lett., 2022, 24, 2441-2445.
DOI: 10.1021/acs.orglett.2c00700
see article for more reactions
Abstract
A dual cobalt- and photoredox-catalyzed HAT hydroarylation of alkenes offers high efficiency in the synthesis of δ-lactams and various other benzo-fused hetercycles compared to established protocols. The proposed mechanism is supported by experiments and DFT calculations.
see article for more examples
proposed mechanism
Key Words
3,4-Dihydroisoquinolones, Ascorbic Acid, Photochemistry
ID: J54-Y2022
