Organic Chemistry Portal



Intramolecular Hydrogen Atom Transfer Hydroarylation of Alkenes toward δ-Lactams Using Cobalt-Photoredox Dual Catalysis

Yuto Yamaguchi, Yusuke Seino, Akihiko Suzuki, Yuji Kamei, Tatsuhiko Yoshino, Masahiro Kojima* and Shigeki Matsunaga*

*Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan, Email:,

Y. Yamaguchi, Y. Seino, A. Suzuki, Y. Kamei, T. Yoshino, M. Kojima, S. Matunaga, Org. Lett., 2022, 24, 2441-2445.

DOI: 10.1021/acs.orglett.2c00700

see article for more reactions


A dual cobalt- and photoredox-catalyzed HAT hydroarylation of alkenes offers high efficiency in the synthesis of δ-lactams and various other benzo-fused hetercycles compared to established protocols. The proposed mechanism is supported by experiments and DFT calculations.

see article for more examples

proposed mechanism

Key Words

3,4-Dihydroisoquinolones, Ascorbic Acid, Photochemistry

ID: J54-Y2022