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Switchable Synthesis of Sulfoxides, Sulfones and Thiosulfonates through Selectfluor-Promoted Oxidation with H2O as O-Source

Xuqiang Guo, Xuejun Sun, Mengmeng Jiang, Yulei Zhao*

*School of Chemistry and Chemical Engineering, Qufu Normal University, Qufu 273165, P. R. of China, Email:

X. Guo, X. Sun, M. Jiang, Y. Zhao, Synthesis, 2022, 54, 1996-2004.

DOI: 10.1055/a-1701-6700


Selectfluor mediates practical and efficient oxidations of sulfides and thiols to provide sulfoxides, sulfones, and thiosulfonates, respectively, at ambient temperature. All these organosulfur compounds can be prepared with nearly quantitative yields by applying eco-friendly H2O as O-source. The formation of sulfoxides and thiosulfonates takes only a few minutes.

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Key Words

oxidation, sulfoxides, sulfones, thiosulfonates, Selectfluor

ID: J66-Y2022