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Cobalt Bromide-Catalyzed Negishi-Type Cross-Coupling of Amides

Céline Dorval, Oleh Stetsiuk, Sylvaine Gaillard, Elodie Dubois, Corinne Gosmini and Grégory Danoun*

*LCM, CNRS, Ecole polytechnique, Institut Polytechnique de Paris, 91120 Palaiseau, France, Email: gregory.danounpolytechnique.edu

C. Dorval, O. Stetsiuk, S. Gaillard, E. Dubois, C. Gosmini, G. Danoun, Org. Lett., 2022, 24, 2778-2782.

DOI: 10.1021/acs.orglett.2c00940


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Abstract

A cobalt bromide salt catalyzes a Negishi-type cross-coupling of of various glutarimide amides with organozinc compounds. The cross-coupling reactions can also be performed in an eco-compatible solvent such as ethyl acetate on a large scale.

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proposed rmechanism



Key Words

acylation


ID: J54-Y2022